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UC Davis Grant Zeroes In On Novel Asthma Diagnosis, Treatment
An entomology professor at the University of California, Davis who discovered a novel therapeutic target for treating inflammation, has received a three-year $750,000 grant from the American Asthma Foundation to investigate whether his discovery will work on asthma, a chronic disease affecting 300 million people worldwide, including 23 million Americans.
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Advocates Express Concern About Embryonic Stem Cell Research Guidelines As Comment Period Closes
Supporters of embryonic stem cell research have expressed concern about the impact on existing research efforts under the Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research, the Washington Post reports. The public comment period for the guidelines ends Tuesday and has generated more than 20,000 comments addressing nearly every element of the proposal. The guidelines, which NIH issued in April, propose limiting federal funding for the research to stem cells derived from unused embryos created for fertility treatments and willingly donated by patients who have given written consent. Former President George W. Bush in August 2001 enacted restrictions limiting federal funding for the research to the 21 stem cell lines existing at the time. Although President Obama in March signed an executive order lifting Bush"s restrictions, some proponents of embryonic stem cell research have suggested that Obama"s plan could actually jeopardize many existing research efforts. The Obama administration is expected to issue its final version of the guidelines by July 7, the Post reports.After Bush restricted federal funding to the embryonic stem cell lines already in existence, many researchers turned to private donors and state governments for the financial support to create hundreds of new lines. Although supporters of the research initially were pleased that the Obama administration"s guidelines would allow federal funding for research on these new existing lines, some are now concerned that certain stipulations in the new guidelines could actually disqualify these research efforts from receiving federal funding. For example, NIH"s proposal requires that couples who wish to donate unused embryos for research sign a consent form indicating that they were fully informed of their alternatives. Although many fertility clinics provide information for couples about their other options, few clinics note these details in written consent forms, according to the Post. Therefore, existing stem cell lines derived from embryos donated by couples who did not sign the required consent forms could be ineligible under NIH"s draft proposal, the Post reports. In addition, many stem cell research supporters also expressed disappointment that only unused embryos created for fertility treatments would be eligible for federal funding.George Daley of the Harvard Stem Cell Institute said that the Obama administration"s guidelines "take 2009 standards and attempt to apply them retroactively, which isn"t really a standard that would allow most of the pre-existing lines to be acceptable for NIH funding." Lawrence Goldstein, director of the University of California-San Diego"s stem cell program, said, "It"s not that past practices were shoddy. But they don"t necessarily meet every letter of the new guidelines moving forward." Goldstein added that researchers would "have to throw everything out and start all over again" under the new proposed guidelines. Amy Comstock Rick, CEO of the Coalition for the Advancement of Medical Research, said that her group is "very concerned" about the funding prospects for existing research efforts, adding that if NIH officials do not modify the guidelines, "very little current research would be eligible" to receive federal funds. However, Raynard Kington, acting NIH director, said the agency is aware of the concerns and "will take them into consideration." He added that "it"s unambiguous that the intent of the president was to expand opportunities and research in this area," as long as such research is "scientifically worthy" and "ethically responsible" (Stein, Washington Post, 5/25).
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Older Cancer Patients Have More Frailty Than Other Seniors
Older people with a history of cancer are more likely to have disabilities and be frail and vulnerable than older adults who have not had cancer, according to a study in the Journal of the National Cancer Institute, published online July 29.
Public Health

Does Mom Know When Enough Is Enough?

As the childhood obesity epidemic in the United States continues, researchers are examining whether early parent and child behaviors contribute to the problem. A study from the Department of Nutritional Sciences, Rutgers University, published in the May/June 2009 issue of the Journal of Nutrition Education and Behavior reports that mothers who miss signs of satiety in their infants tend to overfeed them, leading to excess weight gains during the 6 month to 1 year period. Ninety-six low-income black and Hispanic mothers, who chose to formula feed exclusively, were enrolled in the study. Data was collected during an initial interview and three home visits at 3, 6, and 12 months. During the home visits, feedings were observed, the mothers were interviewed, and the child"s weight was measured. Feeding diaries were also checked for omissions or clarifications. A number of characteristics that predicted infant weight gain from birth to 3 months were included in the analysis. These were birth weight, gender, race/ethnicity, maternal age, education, country of origin, body mass index (BMI) before pregnancy, and weight gain during pregnancy. For the 3 to 6 month period, birth weight, maternal BMI, infant weight gain from birth to 3 months, infant length gain from birth to 3 months, the estimated number of feeds per day, the month that solid food was introduced, and the mothers" sensitivity to the infants" signals at 3 months were included. And, finally, for the 6 to 12 month period, birth weight, maternal BMI, infant weight gain from 3 to 6 months, infant length gain from 3 to 6 months, maternal sensitivity to infant signals at 6 months, and the estimated number of feeds/day at 6 months were entered as the independent variables. None of these variables served to predict infant weight gain over the first 3 months, or similarly, from 3 to 6 months. However, the number of feeds per day at 6 months approached significance in predicting weight gain from 6 to 12 months, and maternal sensitivity to the infants" signals reached predictive significance, but in a negative direction-indicating that mothers who were less sensitive to satiety cues had infants who gained more weight. Writing in the article, John Worobey, PhD; Maria Islas Lopez, MA; and Daniel J. Hoffman, PhD, state, "More frequent feedings, particularly with formula, are an easy culprit on which to assign blame. But maternal sensitivity to the infant"s feeding state, as reflected by the Feeding Scale scores, suggests that an unwillingness to slow the pace of feeding or terminate the feeding when the infant shows satiation cues may be overriding the infant"s ability to self-regulate its intake." However, the researchers warn that, "To use this knowledge to better inform low-income/educated mothers, indeed, mothers of any background who have settled on a feeding method, could pose a daunting challenge. Feeding an infant is a primal behavior, and to suggest to a new mother that she is feeding her infant too often, too much, or worse yet, is not very good at reading her infant"s signals, would require an extremely skilled nurse or social worker. Giving counsel after watching a mother feed her infant might be seen as threatening, or at the very least meddling, and just pointing it out could be construed as an accusation of "poor mothering."" The article is "Maternal Behavior and Infant Weight Gain in the First Year" by John Worobey, PhD; Maria Islas Lopez, MA; and Daniel J. Hoffman, PhD. It appears in the Journal of Nutrition Education and Behavior, Volume 41, Issue 3, (May/June 2009) published by Elsevier. Elsevier


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