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Antisense Therapeutics Drug ATL1101 Enhances Effect Of Existing Chemotherapy Treatment On Prostate Tumors
Antisense Therapeutics Ltd. (ASX: ANP) is pleased to report further positive results from its collaborative preclinical research studies on the therapeutic potential of ATL1101 in prostate cancer. In experimental models, ATL1101 treatment significantly enhanced the tumor-suppressive effect of the cancer drug Paclitaxel. Paclitaxel is one of a class of drugs known as taxanes. Along with androgen (a male hormone) blockade, taxane chemotherapy is an important treatment option in the most dangerous form of the disease, castration-resistant prostate cancer (CRPC).
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System Accurately Predicts Spread Of H1N1
A new scientific system developed by a St. Michael"s Hospital physician, designed to rapidly evaluate the world"s air traffic patterns, accurately predicted how the H1N1 virus would spread around the world, according to research published in the New England Journal of Medicine.
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The End Of The Line For Existing Stem Cell Research?
Time is short for scientists to respond to the call for comments on the National Institutes of Health (NIH) proposed guidelines for the use of human embryonic stem (ES) cell lines and their eligibility for federal funds. On May 26, the window to provide feedback will close, and the drafted rules leave the possibility that funding for almost all existing cell lines will disappear.
Mental Health

Heart Failure Patients With Cognitive Impairment Have Higher Mortality Risk

"There are data in the literature suggesting an increased mortality in patients with chronic heart failure who are additionally suffering from cognitive decline", said Dr. Clotilde Balucani (Perugia, Italy) at the current meeting of the European Neurological Society (ENS). This major meeting in European neurology is gathering more than 2,900 experts from all over the world in Milan. Dr. Balucani and her colleagues are presenting a study funded by a research grant of the ENS. The French-Italian research team analyzed data from three studies involving a total of 896 patients suffering from cardiac insufficiency, half of whom were cognitively impaired. Heart failure is associated with a high mortality rate even among patients not cognitively impaired: 17,9 % (after 6 months), 25,6 % (after 12 months) und 68,2 % (after 60 months). The mortality rate was even much higher in heart failure patients with cognitive impairment, with rates of 35,6 %, 40 % and 96.3 %. "Data are yet too scarce to identify whether this is just the result of an increased morbidity in patients with cognitive impairment or if there is a direct causal relationship due to undertreatment or poor compliance," adds Dr. Balucani who would like to see more research in this area. Abstract: ENS abstract O119: Balucani et al, Does cognitive impairment influence outcome in congestive heart failure? A systematic review. European Neurological Society


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