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Despite Some Progress, Key Senators Say August Deadline A Longshot
One day after President Obama told lawmakers to speed up their pace, three key Finance Committee senators expressed doubts about meeting the President"s August deadline for passing a reform proposal, Politico reports. Sen. Kent Conrad, D-N.D., said he doesn"t "see how" his colleagues can confirm the new Supreme Court nominee, Sonia Sotomayor, and pass a health bill in the time left before the August recess.
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Afinitor(R) Phase II Data Show Positive Results For Patients With Multiple Types Of Lymphoma, Leading To Phase III Trial
New data show that Afinitor(R) (everolimus) tablets significantly shrunk tumors in 33% of patients with relapsed non-Hodgkin"s lymphoma (NHL) and Hodgkin"s disease(1). Based on results from this study and other early-stage research, Novartis has initiated a Phase III trial in the most common NHL, diffuse large B-cell lymphoma (DLBCL).
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Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study Of KRX-0401 (Perifosine) In Recurrent Pediatric Solid Tumors At Memorial Sloan-Kettering Cancer
Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) announced today the initiation of a Phase 1 clinical study to evaluate KRX-0401 (perifosine) as a single agent treatment for recurrent solid tumors in pediatric patients. This Phase 1 study is now open for enrollment at Memorial Sloan-Kettering Cancer Center in New York City. Oren Becher, MD, Instructor, Department of Pediatrics, in coordination with Eric Holland, MD, PhD, Director of the Brain Tumor group at Memorial Sloan-Kettering Cancer Center, will act as the study"s Principal Investigator. The study announced is being fully funded by an external grant provided by a private organization.
Endocrinology

Nepean Dyspepsia Index Applies To Functional Dyspepsia In China

FD, a common non-organic disease in the world, greatly affects a patient"s quality of life. However, treatment of FD is still controversial and no single therapy is uniformly effective, due, in part, to absence of a reliable evaluation instrument. The Nepean Dyspepsia Index (NDI), measuring both symptom scores and impairment of the dyspepsia-specific health-related quality of life in FD patients, has been designed to diagnose FD and has been translated into several languages. Moreover, its utility has been proved to be validated by researches in western countries. However, DI has not been translated and validated in China. A research article published in the World Journal of Gastroenterology addresses this problem. The research team led by Professor Liang from Chengdu University of Traditional Chinese Medicine translated NDI and assessed the reliability and validity of this translated version in Chinese patients. According to the WHO-QOL methodology of cross-culture adaptation for quality of life, the NDI was formally translated from the original version into Chinese, including forward translation, back translation, a pretest and cross-cultural adaptation. In addition, internal consistency analysis with Cronbath"s alpha was performed to test its reliability. Pearson Item-Dimension Correlation coefficient was employed to evaluate content validity. Factor analysis and structural equation models were used to assess construct validity. The study indicated that the Chinese version of the NDI is a reliable and valid scale for measuring health-related quality of life (H-QOL) and disease severity in Chinese patients with functional dyspepsia. It is recommended to be used in FD-related clinical research in China in the future. Reference: Tian XP, Li Y, Liang FR, Sun GJ, Yan J, Chang XR, Ma TT,Yu SY, Yang XG. Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China. World J Gastroenterol 2009; 15(25): 3173-3177 http://www.wjgnet.com/1007-9327/15/3173.asp Correspondence to: Fan-Rong Liang, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China. Lin Tian World Journal of Gastroenterology


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