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Major League Diabetes
It may have been the biggest curveball of Seattle Mariners pitcher Brandon Morrow"s life: type 1 diabetes. Diabetes Forecast, the consumer magazine of the American Diabetes Association, features an interview with the bazooka-armed athlete in the July 2009 issue. Morrow shares insights on being a professional athlete while managing a chronic disease, his decision to stay in the bullpen, his supportive teammates and his unique and unexpected opportunity to mentor fellow Mariners reliever Mark Lowe, who also has diabetes.
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University Of Pittsburgh Schools Of The Health Sciences Announce New Research Funding
Innovative research conducted by faculty of the University of Pittsburgh Schools of the Health Sciences contributes to a better understanding of the causes and origins of disease and aids in the development of more effective treatment approaches. Government and private-sector funding is critical to this process of scientific inquiry. The following projects recently have been awarded grants that will enable the continuation of existing projects or the pursuit of new areas of investigation:
News of the day
Lyme Disease Is Spreading In Canada, And Physicians Are Crucial In Helping Minimize Its Impact
Lyme disease is emerging in Canada, and is expected to increase with climate change, but effective, enhanced surveillance and clinician awareness will be key to minimizing the impact of the disease, write researchers in a review in CMAJ .
Medical Devices

Quinine Side Effects May Be Result Of Tryptophan Deficiency

Researchers have found that the anti-malarial drug quinine can block a cell"s ability to take up the essential amino acid tryptophan, a discovery that may explain many of the adverse side-effects associated with quinine. Once confirmed, these findings would suggest that dietary tryptophan supplements could be a simple and inexpensive way to improve the performance of this important drug. Quinine is a very commonly used anti-malarial drug, yet to this day the principal mode of quinine action against the malaria parasite is still largely unclear, as is the basis for adverse reactions like nausea, headaches, and blurred vision. To address these gaps, Simon Avery and colleagues at the University of Nottingham took advantage of yeast genetics, examining the effects of quinine on a collection of 6000 yeast mutants, each one lacking exactly one of the yeast"s 6000 genes. While quite different from humans, yeast is comparable on a cellular level and yeast is frequently, and successfully, used as front-line agents in testing chemicals and small molecule drugs. Their screen revealed that strains unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external s, and thus die if tryptophan transport is blocked). This discovery fits in well with evidence that quinine reactions are more severe in malnourished individuals. Unlike yeast, humans cannot make their own tryptophan and thus require dietary tryptophan, which is abundant in meat but limited in yams, a staple food crop in the tropics where malaria is prevalent. If quinine severely reduces tryptophan uptake, then it follows that people with preexisting tryptophan deficiencies would be especially at risk to this drug. The authors also note that tryptophan is important as a precursor for the brain chemical serotonin, so the enhanced tryptophan deficiency induced by quinine could explain why many of quinine"s side effects are localized to the head region. They also note that side-effects could be averted simply by taking dietary tryptophan supplements in conjunction with quinine treatments, though it is not yet known if tryptophan may affect quinine action against the malaria parasite. This study appears in the July 3rd issue of Journal of Biological Chemistry and was published online June 26. From the Article: "THE ANTIMALARIAL DRUG QUININE DISRUPTS TAT2P-MEDIATED TRYPTOPHAN TRANSPORT AND CAUSES TRP STARVATION" by Combiz Khozoie, Richard J. Pleass and Simon V. Avery Nick Zagorski American Society for Biochemistry and Molecular Biology


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