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Tackling Major Health Challenges In England - The King's Fund Reveals New Approach To Supporting The NHS
The King"s Fund has announced a series of new initiatives and projects to take forward its work to improve health care.
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Study Finds Many Newborns Of South Asian And East Asian Descent Misclassified As Underweight At Birth
Babies of East Asian and South Asian descent are between two and three times more likely to be misclassified as underweight at birth when compared to their Canadian counterparts, according to a study led by St. Michael"s Hospital physician Dr. Joel Ray. Dr. Ray and a team of researchers, who developed the first-ever sex-specific birth weight curves for these ethnic groups, suggest the need to consider differences across ethnic groups to reduce parental stress and use of health-care res associated with labelling an infant as underweight, or "small for gestational age" at birth.
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New Pocket-Sized Breath Test Developed By TAU
A quick breath check in the palm of your hand can never give accurate results. Whether you"re about to lean in for a smooch or start a job interview, you"re better off asking a trusted friend if your breath is sweet. But what if a friend isn"t around when you need one?
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Sleep And Weight Gain: A Molecular Link

There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity. Previous studies have shown that mice lacking the CaV3.1 T-type calcium channel have disrupted sleep/wake activity. In this study, the researchers found that these mice were resistant to weight gain when fed a high-fat diet. Consistent with these data, when normal-weight rodents were administered a drug that specifically antagonized T-type calcium channels during their inactive phase they showed increased sleep and were protected from weight gain due to a high-fat diet. Further, when the same drug was given to obese rodents it reduced body weight and fat mass. The authors conclude that the benefits of the drug are likely to be a result of better alignment of feeding patterns and the circadian rhythm, and that targeting T-type calcium channels might provide a new avenue of research for those developing drugs to treat obesity. TITLE: Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice AUTHOR CONTACT: Victor N. Uebele Merck Research Laboratories, West Point, Pennsylvania, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=36954 Karen Honey Journal of Clinical Investigation


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