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Lawmakers Seek Price Tag They Can Agree On
"Lawmakers working to overhaul the U.S. health-care system face a pressure-filled July after leaving town this week without resolving the biggest questions dividing Democrats and Republicans," Bloomberg reports. Democrats on the Senate Finance Committee - which observers deem most likely to come up with a passable, bipartisan bill - have been working to reduce the cost of the overhaul to gain Republican support, but had not yet released a proposal. Bloomberg adds: "While the Congressional Budget Office said options under consideration by the committee can keep the cost within Baucus"s goal of $1 trillion over 10 years, how to pay for the plan remains unsettled. So is structuring some kind of government-run competition for insurers. ... "Nothing has been set," Montana Democrat [Max] Baucus told reporters in the Capitol on June 25. The recess offers a chance for "taking stock," he said" (Jensen and Livkin, 6/29).
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Identification Of Molecular Powerbrokers Involved In Cancer's Spread
You know the guy - he"s your Facebook friend. The one who knows everyone. Secure at the center of a dense web of relationships, he suggests causes and reconnects old friends like a skilled matchmaker. Scientists have known for some time that biological molecules interact with one another in a similarly complex pattern. Now researchers at the Stanford University School of Medicine have determined that hamstringing these molecular powerbrokers is a good way to derail processes such as cancer development.
News of the day
JAOtech Launch Anti-bacterial, Self-monitoring Keyboards
New wireless keyboards for use with hospital patient entertainment and point-of-care terminals are hygienic, monitoring their own disinfect status to give reminders when sterilisation is due.
Public Health

Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer. The researchers show that - even though both cell volume and the length of the contractile ring are reduced during successive rounds of embryonic cell division - the duration or timing of cell division remains the same. Their study was published in the May 29 issue of the journal Cell. "We showed that contractile rings constrict at a constant rate that is proportional to the initial size of the cell, so that rings in larger cells constrict proportionally faster than rings in smaller cells," said Karen Oegema, PhD, associate professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine and the Moores UCSD Cancer Center. "Because of this property, the time required to complete cell division remains the same during embryogenesis, even as cells get smaller." During their early development, embryos are progressively partitioned into smaller and smaller cells by successive rounds of cell division. The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell. A contractile ring forms a belt around the cell middle; constriction or closure of this ring "tightens the belt," pinching the mother cell into two daughter cells. In early embryogenesis, cell volume and the length of the contractile ring around the cell middle are reduced at each successive round of cell division. By contrast, the dimension of the chromosomes - which carry the genetic material that is segregated to the daughter cells - remains constant. The discovery that contractile rings constrict at a constant rate, proportionate to the initial cell size, opens the door to further studies of the mechanism. "Further studies of the contractile ring could ultimately lead to improved therapies for cancer," said first author Ana Carvalho, PhD. "Understanding the cellular machinery required for cell division may teach us how to prevent the uncontrolled cell division that occurs in cancer." Arshad Desai, PhD, professor at the Ludwig Institute and assistant professor of cellular and molecular medicine at UCSD also contributed to the paper. Funding was provided by the Ludwig Institute for Cancer Research, the Pew Scholars Program in the Biomedical Sciences, the FundaÃýão para a Ciência e Tecnologia, Portugal, and The European Social Fund. Steve Benowitz University of California - San Diego


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