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Mersana Reports Preliminary Phase 1 Results Of XMT-1001 In Patients With Advanced Solid Tumors
Mersana Therapeutics presented preliminary results of a Phase 1 clinical trial for its lead development candidate, XMT-1001, in a poster session at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando. XMT-1001 is a broad-spectrum cytotoxic, based on camptothecin (CPT), conjugated to Mersana"s biodegradable polymer platform, Fleximer(R).
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Migraines With Aura In Middle Age May Be Associated With Late Life Brain Lesions
Women who suffer from migraine headaches in middle age particularly those accompanied by neurological aura are more likely to have damage to brain tissue in the cerebellum later in life, according to a study by researchers at the Uniformed Services University of the Health Sciences, the National Institute on Aging (NIA) of the National Institutes of Health (NIH) and the Icelandic Heart Association in Reykjavik. The study appears in the June 24, 2009, issue of the Journal of the American Medical Association. The researchers found that migraine sufferers with aura are more susceptible than others to localized brain tissue damage identified on magnetic resonance images (MRI). In particular, women who reported having migraines with aura were almost twice as likely to have such damage in the cerebellum as women who reported not having headaches.
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World's First Deep Brain Stimulation Device Approved For Treatment Of Psychiatric Condition In Europe
Medtronic announced that Reclaim(R) Deep Brain Stimulation (DBS) Therapy has received CE (Conformite Europeene) Mark approval for the treatment of chronic, severe treatment-resistant obsessive-compulsive disorder (OCD). This is the first time that a deep brain stimulation therapy has gained approval in Europe for the treatment of a psychiatric disorder.
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Study Shows The Negative Side To Positive Self-Statements In Self-Help Books

In times of doubt and uncertainty, many Americans turn to self-help books in search of encouragement, guidance and self-affirmation. The positive self-statements suggested in these books, such as "I am a lovable person" or "I will succeed," are designed to lift a person"s low self-esteem and push them into positive action. According to a recent study in Psychological Science, a journal of the Association for Psychological Science, however, these statements can actually have the opposite effect. Psychologists Joanne V. Wood and John W. Lee from the University of Waterloo, and W.Q. Elaine Perunovic from the University of New Brunswick, found that individuals with low self-esteem actually felt worse about themselves after repeating positive self-statements. The researchers asked participants with low self-esteem and high self-esteem to repeat the self-help book phrase "I am a lovable person." The psychologists then measured the participants" moods and their momentary feelings about themselves. As it turned out, the individuals with low self-esteem felt worse after repeating the positive self-statement compared to another low self-esteem group who did not repeat the self-statement. The individuals with high self-esteem felt better after repeating the positive self-statement - but only slightly. In a follow-up study, the psychologists allowed the participants to list negative self-thoughts along with positive self-thoughts. They found that, paradoxically, low self-esteem participants" moods fared better when they were allowed to have negative thoughts than when they were asked to focus exclusively on affirmative thoughts. The psychologists suggested that, like overly positive praise, unreasonably positive self-statements, such as "I accept myself completely," can provoke contradictory thoughts in individuals with low self-esteem. Such negative thoughts can overwhelm the positive thoughts. And, if people are instructed to focus exclusively on positive thoughts, they may find negative thoughts to be especially discouraging. As the authors concluded, "Repeating positive self-statements may benefit certain people [such as individuals with high self-esteem] but backfire for the very people who need them the most." Katie Kline Association for Psychological Science


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